Diversity of medicinal plant uses and epidemiological analysis during the COVID-19 pandemic in Biskra (south-eastern of Algeria)
Journal cover Biodiversity: Research and Conservation, volume 78, year 2025
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Keywords

COVID-19
chronic disease
traditional medicine
medicinal plants
ethnopharmacology
mortality
Biskra

How to Cite

Dehimat, A., Hemidi, K., Segueni, N., & Bendif, H. (2025). Diversity of medicinal plant uses and epidemiological analysis during the COVID-19 pandemic in Biskra (south-eastern of Algeria). Biodiversity: Research and Conservation, 78, 21–33. https://doi.org/10.14746/biorc.2025.78.2

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Abstract

In this study we examined data on COVID-19 patients recorded in 2020 at the Hakim Sadanne Hospital in the Biskra, Algeria and applied various tests: statistical, epidemiological, etc. In addition, we conducted interviews with herbalists and an ethnobotanical on-line survey of medicinal plants used during the COVID-19 pandemic. A total of 2108 cases of this disease, including 931 deaths, were analysed to link various factors, such as air temperature, age, and sex, with mortality rate. Our results demonstrate that the appearance of symptoms of infection was often associated with pre-existing chronic diseases, particularly diabetes, cardiovascular heart disease, and high blood pressure. As for medicinal plants, Melissa officinalis and Zingiber officinale were the most used during the pandemic, whereas Eucalyptus globulus and Syzygium aromaticum had 100% fidelity levels. In conclusion, primarily the above-mentioned chronic diseases were associated with reduced immunity to COVID-19. Furthermore, traditional medicine has been an accommodating alternative to conventional medical treatment of COVID-19 within Biskra region.

https://doi.org/10.14746/biorc.2025.78.2
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References

Ali-Shtayeh M. S., Jamous R. M., Abu-Zaitoun S. Y., Khasati A. I. & Kalbouneh S. R. 2019. Biological properties and bioactive components of Mentha spicata L. essential oil: Focus on potential benefits in the treatment of obesity, Alzheimer‘s disease, dermatophytosis, and drug-resistant infections. Evidence-Based Complementary and Alternative Medicine 2019: 1-11. DOI: https://doi.org/10.1155/2019/3834265

Al-Jamal H., Idriss S., Roufayel R., Abi Khattar Z., Fajloun Z. & Sabatier J.-M. 2024. Treating COVID-19 with medicinal plants: Is it even conceivable? A comprehensive review. Viruses 16, 320. DOI: https://doi.org/10.3390/v16030320

Appiah D. T., Assogbadjo A. E., Chadare F. J., Zanvo S. & Sinsin B. 2016. Approches méthodologiques synthétisées des études d‘ethnobotanique quantitative en milieu tropical. Annales des sciences agronomiques 20 :187-205.

Appiah K. S., Mardani H. K., Osivand A., Kpabitey S., Amoatey C. A., Oikawa Y. & Fujii Y. 2017. Exploring alternative use of medicinal plants for sustainable weed management. Sustainability 9(8): 1468. DOI: https://doi.org/10.3390/su9081468

Asai T. 2020. COVID-19: Accurate interpretation of diagnostic tests-a statistical point of view. Journal of Anesthesia 35(3): 328-332. DOI: https://doi.org/10.1007/s00540-020-02875-8

Ay Kee L., Bakr Shori A. & Salihin Baba A. 2017. Bioactivity and health effects of Mentha spicata. Integrative Food, Nutrition and Metabolism 5(1): 1-2. DOI: https://doi.org/10.15761/IFNM.1000203

Bagheri S. M., Heydari M. & Ramezani M. 2018. A review of the pharmacological properties of Saussurea costus (Falc.) Lipsch. Journal of Herbal Medicine 12: 1-9.

Butler C. C., Dorward J., Yu L.-M., Gbinigie O., Hayward G., Saville B. R., Van Hecke O., Berry N., Detry M., Saunders Ch., Fitzgerald M., Harris V., Patel M. G., de Lusignan S., Ogburn E., Evans P. H., Thomas N. P. B. & Hobbs F. D. R. 2021. Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomized, controlled, open-label, adaptive platform trial. Lancet 397(10279): 1063-1074. DOI: https://doi.org/10.1016/S0140-6736(21)00461-X

Bwire G. M. 2020. Coronavirus: Why men are more vulnerable to Covid-19 than women? SN Comprehensive Clinical Medicine 2(7): 874-876. DOI: https://doi.org/10.1007/s42399-020-00341-w

Chaachouay N., Douira A. & Zidane L. 2021. COVID-19, prevention and treatment with herbal medicine in the herbal markets of Salé Prefecture, North-Western Morocco. European Journal of Integrative Medicine 42: 101285. DOI: https://doi.org/10.1016/j.eujim.2021.101285

Cortés-Rojas D. F., De Souza C. R. F. & OliveiraW. P. 2014. Clove (Syzygium aromaticum): a precious spice. Asian Pacific Journal of Tropical Biomedicine 4(2): 90-96. DOI: https://doi.org/10.1016/S2221-1691(14)60215-X

Dossou-Yovo H. O., Vodouhè F. G., Kaplan A. & Sinsin B. 2022. Application of Ethnobotanical Indices in the Utilization of Five Medicinal Herbaceous Plant Species in Benin, West Africa. Diversity 14, 612. DOI: https://doi.org/10.3390/d14080612

Ekiert H., Pajor J., Klin P., Rzepiela A., Ślesak H. & Szopa A. 2020. Significance of Artemisia vulgaris L. (Common Mugwort) in the history of medicine and its possible contemporary applications substantiated by phytochemical and pharmacological studies. Molecules 25(19): 4415. DOI: https://doi.org/10.3390/molecules25194415

Fang X., Li S., Yu H., Wang P., Zhang Y., Chen Z., Li Y., Cheng L., Li W., Jia H. & Ma X. 2020. Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis. Aging (Albany NY). 12(13): 12493-12503. DOI: https://doi.org/10.18632/aging.103579

Guo T., Fan Y., Chen M., Wu X., Zhang L., He T., Wang H., Wan J., Wang X. & Lu Z. 2020. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiology 5(7): 811. DOI: https://doi.org/10.1001/jamacardio.2020.1017

Hemidi K. & Dehimat A. 2021. COVID-19 in people with chronic diseases: understanding the reasons for worse outcomes. The National Day on SARS-CoV-2 Bioinformatics and Biotechnology. Algerian Journal of Health Sciences 34-35.

Hofmann H., Pyrc K., Hoek L. van der, Geier M., Berkhout B. & Pöhlmann S. 2005. Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proceedings of the National Academy of Sciences of the United States of America (16): 16. DOI: https://doi.org/10.1073/pnas.0409465102

Jamshidi S., Baniasad M. & Niyogi D. 2020. Global to USA county scale analysis of weather, urban density, mobility, homestay, and mask use on COVID-19. International Journal of Environmental Research and Public Health 17(21): 7847. DOI: https://doi.org/10.3390/ijerph17217847

Karnam G., Rygiel T. P., Raaben M., Grinwis G. C. M., Coenjaerts F. E. & Ressing M. E. 2012. CD200 Receptor controls sex-specific TLR7 responses to viral infection. PLoS Pathogens 8(5): e1002710. DOI: https://doi.org/10.1371/journal.ppat.1002710

Kshirsagar S. G. & Rao R. V. 2021. Antiviral and immunomodulation effects of Artemisia. Medicina 57(3): 217. DOI: https://doi.org/10.3390/medicina57030217

Kumar M., Taki K. & Gahlot R. 2021. Ethnopharmacological and phytochemical aspects of medicinal plants used in COVID-19: A comprehensive review. Journal of Ethnopharmacology 283: 114571.

Lee W. S. & Rhee D.-K. 2021. Corona-Cov-2 (COVID-19) and ginseng: Comparison of possible use in COVID-19 and influenza. Journal of Ginseng Research 45(4): 535-537. DOI: https://doi.org/10.1016/j.jgr.2020.12.005

Leonti M. & Casu L. 2013. Traditional medicines and globalization: current and future perspectives in ethnopharmacology. Front Pharmacol. 4: 92. DOI: https://doi.org/10.3389/fphar.2013.00092

Miraj S., Kopaei R., Kiani S. 2017. Melissa officinalis L: A Review Study With an Antioxidant Prospective. Journal of Evidence-Based Complementary & Alternative Medicine 22(3): 385-394. DOI: https://doi.org/10.1177/2156587216663433

Nishiura H. & Chowell G. 2009. The effective reproduction number as a prelude to statistical estimation of time-dependent epidemic trends. Mathematical and statistical estimation approaches in epidemiology. Springer. p. 103-121. DOI: https://doi.org/10.1007/978-90-481-2313-1_5

Orege J. I., Adeyemi S. B., Tiamiyu B. B., Akinyemi T. O., Ibrahim Y. A. & Orege O. B. 2023. Artemisia and Artemisia-based products for COVID-19 management: current state and future perspective. Adv Tradit Med (ADTM) 23(1): 85-96. DOI: https://doi.org/10.1007/s13596-021-00576-5

Othman M. 2013. Anti-bacterial effect of Indian costus and sea-qust and their water extracts on some pathogenic bacteria of the human respiratory system. Journal of Medicinal Plants Research 7(20): 1418-1423.

Prasanth D., Manikanta M., Chandramohan V., Bhavya G., Lakshmana Rao A., Panda S. P., Rao G., Chakravarthi G., Teja N., Suguna Rani P., Ashu G., Purnadurganjali C., Akhil P., Vedita Bhavani G. & Jaswitha T. 2021. In-silico strategies of some selected phytoconstituents from Melissa officinalis as SARS CoV-2 main protease and spike protein (COVID-19) inhibitors. Molecular Simulation: 1-14. DOI: https://doi.org/10.1080/08927022.2021.1880576

Quintiliani R. 1996. Cefixime: A pharmacoeconomic perspective. Current Therapeutic Research 57(12): 892-912. DOI: https://doi.org/10.1016/S0011-393X(96)80109-3

WHO 2023. World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV). Retrieved in January 2025 from https://www.who.int/news-room/fact-sheets/detail/coronavirus-disease-(covid-19).

Zahnit W., Smara O., Bechki L., Bensouici C., Messaoudi M., Benchikha N., Larkem I., Awuchi C. G., Sawicka B. & Simal-Gandara J. 2022. Phytochemical Profiling, Mineral Elements, and Biological Activities of Artemisia campestris L. Grown in Algeria. Horticulturae 8(10): 914. DOI: https://doi.org/10.3390/horticulturae8100914

Zhao T., Li S. J., Zhang Z. X., Zhang M. L., Shi Q.-W. & Gu Y. C. 2017. Chemical constituents from the genus Saussurea and their biological activities. Heterocyclic Communications 23(5): 331-358. DOI: https://doi.org/10.1515/hc-2017-0069